Can You Tell if Your Mole is Cancerous?

By Paul J. Weber, M.D., P.A. | Moles can be good or bad, sometimes even experts have difficulty agreeing about which moles are good and bad. However, knowledge of moles is important because, among other reasons at least one out of every three melanoma skin cancers arises in a mole. Because melanoma is lethal if untreated, improved public knowledge of moles and melanoma can and will save lives. The chances that an American will develop melanoma are rapidly rising. If current trends continue, one in every one hundred Americans born today will eventually develop melanoma. One in every five patients who develop melanoma will die from it.

The terms mole and nevus (plural: moles and nevi) mean the same thing and can be used interchangeably. In this article we will use lots of parentheses to indicate that these words that can mean the same thing. Even the experts in the field of dermatology do not agree on the use of all of these terms.

Melanoma tends to occur in adults in the prime of their family and professional lives. Traits and factors associated with melanoma include having many typical (normal) moles, any atypical moles, familial atypical mole syndrome, familial melanoma syndrome, disorders of DNA repair, excessive sun exposure (for your genetic background), freckling, history of severe sunburn, ease of burning, inability to tan, blue eyes and light hair.

Nevi (moles) can look like beauty marks (e.g., Cindy Crawford) or they can protrude like a bump on a witch’s chin (common nevus). Most people have between 10 and 40 moles. Darker skinned persons frequently have darker colored moles. Moles can range in color from pink to tan to brown to black to blue to normal skin tone. Nevi are made of cells called nevo-melanocytes. Nevo-melanocytes, as the name suggests, are cells that exist along the spectrum between nevus (mole) cells and melanocytes. These nevo-melanocyte cells can be totally benign in nature (common nevus cells) or they may become or appear more abnormal, resulting in atypical (dysplastic) moles and even melanoma.

The true behavior of a nevo-melanocytic mole is usually best determined by biopsying (cutting a sample of) the mole and examining the biopsy specimen under the microscope. The website author believes that a microscopic result is more important than the doctor’s clinical naked-eye diagnosis.

However, the dermatologist’s clinical examination by eye is also important because it sets up the biopsy in which the true nature of the mole can be discovered. The medical importance of nevi (how they can affect our health) rests in knowing that some nevi can signal or develop into melanoma, a deadly from of skin cancer. Knowing the A, B, C, Ds of pigmented lesions can help save a life by finding and curing a melanoma.

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Fortunately, the A, B, C, Ds have made teaching patients about “bad moles” and melanoma inspection easier, but the A, B, C, Ds are not foolproof or even “expert proof.” They may not be as simple as they sound, or maybe not enough doctors understand them. For example, it has been well shown by many studies and quizzes given to doctors of all specialties using a biopsy-proven, obvious, everyday smattering of important pigmented skin lesions (good and bad moles and melanomas) that most non-dermatologists have a high failure rate at correct diagnosis.

All removed moles, even benign-looking ones, should be sent to pathology for microscopic examination, just in case. The microscopic examination helps to tell us whether the mole is harmless. Sometimes moles that are textbook examples of benign or “good” moles turn out to be serious melanoma, discovered incidentally on a 1 of 1000 chance. If a typical doctor’s practice sees several thousand such patients every 3 to 5 years, that may be a chance save a life.

10% of melanomas may not fit the classic dermatologists’ rules for malignancy. Since early detection and removal is the best way to cure melanoma, the patient can participate actively in his/her own care by self-examination. Signs of concern include a mole’s recent change in appearance, size, shape or color, irregularity in color, loss of a uniform border, asymmetry, bleeding and notching of a border. Moles with any of these signs should be brought immediately to the attention of a dermatologist for close scrutiny of the lesion.

Paul J. Weber, M.D., P.A.
5353 North Federal Highway, Suite 400
Fort Lauderdale, FL 33308
Tel: 954-489-9800 | Fax: 954-489-0401